Hydrocodone and oxycodone are similar opioids frequently prescribed to treat pain, but the drugs differ in their available dosage, forms and strengths.

Hydrocodone and oxycodone are opioids frequently prescribed to treat pain. Hydrocodone is usually combined with acetaminophen to make products like Vicodin, and in 2019 this combination was the most common pain-relieving therapy prescribed in the U.S., with more than 30 million prescriptions. Oxycodone is also a common pain reliever, with more than 14 million prescriptions in 2019 and an additional 11 million prescriptions when combined with acetaminophen to make drugs like Percocet. However, despite their similarities, the drugs have important differences.

Is Hydrocodone the Same as Oxycodone?

Hydrocodone is not the same drug as oxycodone. Although they are both semisynthetic opioids and Schedule II controlled substances, they differ in many ways. This includes their strength and available dosage forms.

What Is Hydrocodone (Vicodin)?

Hydrocodone is an opioid and Schedule II controlled substance. It is usually sold combined with other drugs like acetaminophen and is the most common prescription analgesic in the U.S. 

Hydrocodone is available on its own in a long-acting dosage form called Hysingla ER. When combined with acetaminophen, it is available as a generic drug and under the brand names: 

  • Lortab
  • Verdrocet
  • Xodol

Previously, hydrocodone/acetaminophen was also available under the brand names Vicodin, Lorcet and Norco, but these have been discontinued, although some people still use the names conversationally to refer to the drug.

What Is Oxycodone (Percocet)?

Oxycodone is an opioid and Schedule II controlled substance. It is one of the most common analgesics in the U.S., both alone and when prescribed with acetaminophen. 

Oxycodone is sold on its own under several brand names in long-acting and short-acting dosage forms. These include:

  • OxyContin
  • Oxaydo
  • Roxicodone
  • RoxyBond
  • Xtampza ER

The drug is also sold combined with acetaminophen available under brand names like:

  • Percocet
  • Endocet
  • Nalocet
  • Prolate

The combination was previously available under the brand name Primlev, which has been discontinued.

Vicodin vs. Percocet

Hydrocodone/acetaminophen (Vicodin) and oxycodone/acetaminophen (Percocet) are similar drugs in many ways. After all, they are both opioids sold combined with acetaminophen. However, for all their similarities, the drugs also have some key differences.

Drug Class/Scheduling

Both hydrocodone/acetaminophen and oxycodone/acetaminophen are Schedule II controlled substances. This means they can put a person at high risk of abuse, addiction and dependence. For this reason, the drugs should only be taken as prescribed by your doctor and for the shortest duration possible.


The main difference between hydrocodone and oxycodone is their strength. Oxycodone is the stronger of the two drugs and about 1.5 timesas potent as hydrocodone. In other words, 30 mg of hydrocodone is equivalent to 20 mg of oxycodone.


Hydrocodone on its own is only available as oral tablets. However, when combined with acetaminophen, it is available as oral tablets and as an oral solution.

In contrast, oxycodone, both alone and combined with acetaminophen, is available as oral tablets and liquids.


The doses of hydrocodone/acetaminophen and oxycodone/acetaminophen are similar:

Hydrocodone/acetaminophen dosesOxycodone/acetaminophen doses
5 mg hydrocodone/325 mg acetaminophen2.5 mg oxycodone/300 mg acetaminophen
7.5 mg hydrocodone/300 mg acetaminophen2.5 mg oxycodone/325 mg acetaminophen
7.5 mg hydrocodone/325 mg acetaminophen5 mg oxycodone/300 mg acetaminophen
10 mg hydrocodone/300 mg acetaminophen5 mg oxycodone/325 mg acetaminophen
10 mg hydrocodone/325 mg acetaminophen7.5 mg oxycodone/300 mg acetaminophen
7.5 mg oxycodone/325 mg acetaminophen
10 mg oxycodone/300 mg acetaminophen
10 mg oxycodone/325 mg acetaminophen

Side Effects

Hydrocodone/acetaminophen and oxycodone/acetaminophen have similar side effects. These include:

  • Light-headedness or dizziness
  • Sedation
  • Nausea and vomiting
  • Constipation

Drug Interactions

As central nervous system depressants, hydrocodone/acetaminophen and oxycodone/acetaminophen have similar drug interactions. They both carry boxed warnings for drug interactions including: 

  • Use with other acetaminophen products, which can lead to liver damage. 
  • Use with other central nervous system depressants, especially benzodiazepines, which can lead to overdose. In 2020, 16% of opioid overdose deaths involved benzos.

Can You Take Oxycodone and Hydrocodone Together?

Generally, you should not take oxycodone and hydrocodone together; they are usually not prescribed together. This is because oxycodone is stronger than hydrocodone, so a person whose pain requires oxycodone is unlikely to benefit from the much-weaker hydrocodone.

However, there are exceptions. For example, a person may be prescribed a long-acting oxycodone product like OxyContin and a short-acting hydrocodone product like Norco for breakthrough pain.

Because the drugs are both opioids, you should never take them together unless specifically told to by your doctor. The dangers of mixing oxycodone and hydrocodone include liver toxicity from the acetaminophen components, increased side effects and overdose, which can be fatal.

Signs of Hydrocodone and Oxycodone Addiction 

When a person struggles with hydrocodone or oxycodone, symptoms of addiction generally emerge. These include:

  • Taking more of the opioid or for a longer time than intended
  • Previous unsuccessful efforts to cut down on opioid use
  • Spending a lot of time trying to obtain, use or recover from the opioid.
  • Craving the opioid
  • Failing to meet obligations due to the opioid
  • Social problems caused by the opioids
  • Giving up on other activities because of opioid use
  • Using the opioid even when it is physically dangerous to do so
  • Continuing to use the opioid even though you know that doing so is harmful
  • Needing higher doses of the opioid to get the same effects as before
  • Withdrawal symptoms when you try to stop the opioid

Treatment for Opioid Addiction in South Jersey

If you or someone you love struggles with hydrocodone, oxycodone or other opioids, it can be difficult to stop on your own. Fortunately, help is available. The Recovery Village Cherry Hill at Cooper offers a state-of-the-art setting for you to overcome your opioid use. This includes amenities like a fitness facility, basketball and volleyball courts and a yoga studio. Our treatment plans are customized to your needs, and we give you a full continuum of care from medical detox to inpatient and outpatient rehab. Don’t wait: contact us today to learn how we can help.

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Editor – Theresa Valenzky
Theresa Valenzky graduated from the University of Akron with a Bachelor of Arts in News/Mass Media Communication and a certificate in psychology. She is passionate about providing genuine information to encourage and guide healing in all aspects of life. Read more
Medically Reviewed By – Dr. Jessica Pyhtila, PharmD
Dr. Jessica Pyhtila is a Clinical Pharmacy Specialist based in Baltimore, Maryland with practice sites in inpatient palliative care and outpatient primary care at the Department of Veteran Affairs. Read more

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Drug Enforcement Administration. “Controlled Substances.” August 2, 2022. Accessed August 28, 2022.

Drugs.com. “Hydrocodone and Acetaminophen.” May 1, 2021. Accessed August 28, 2022.

Drugs.com. “Oxycodone and Acetaminophen.” May 1, 2021. Accessed August 28, 2022.

National Institute on Drug Abuse. “Benzodiazepines and Opioids.” April 21, 2022. Accessed August 28, 2022.

American Academy of Family Physicians. “Opioid Conversion Table.”  Accessed August 28, 2022.

PsychDB. “Opioid Use Disorder.” May 3, 2021. Accessed August 28, 2022.

Medical Disclaimer

The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.